{"id":493,"date":"2024-04-23T21:55:08","date_gmt":"2024-04-23T19:55:08","guid":{"rendered":"https:\/\/phos4nova.eu\/?page_id=493"},"modified":"2025-05-09T13:19:32","modified_gmt":"2025-05-09T11:19:32","slug":"application-areas","status":"publish","type":"page","link":"https:\/\/phos4nova.eu\/?page_id=493","title":{"rendered":"Our Technology"},"content":{"rendered":"\n<div style=\"height:25px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div style=\"height:0px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-cover alignfull is-light\" style=\"min-height:334px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim-80 has-background-dim\" style=\"background-color:#8fafd5\"><\/span><img fetchpriority=\"high\" decoding=\"async\" width=\"1920\" height=\"1080\" class=\"wp-block-cover__image-background wp-image-463\" alt=\"\" src=\"https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/04\/4.png\" data-object-fit=\"cover\" srcset=\"https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/04\/4.png 1920w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/04\/4-300x169.png 300w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/04\/4-1024x576.png 1024w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/04\/4-768x432.png 768w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/04\/4-1536x864.png 1536w\" sizes=\"(max-width: 1920px) 100vw, 1920px\" \/><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<div class=\"wp-block-uagb-container uagb-block-8bad3b3e alignwide uagb-is-root-container\">\n<div class=\"wp-block-uagb-container uagb-block-239955bb\">\n<h2 class=\"wp-block-heading has-text-align-left has-neve-text-color-color has-text-color\">Our technology helps clinicians achieve early diagnoses and effective therapies, while enabling scientists to develop new therapeutic materials.<\/h2>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<div style=\"height:33px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading alignfull has-text-align-center has-nv-site-bg-color has-midnight-gradient-background has-text-color has-background has-link-color wp-elements-dc2bbdf57fbc39aaabde337384d65688\">Phos4MR Revolutionizing medical imaging and materials through the world\u2019s first polymers with inherent imaging signal<\/h2>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading has-text-align-center\">TECHNOLOGY: Phos4MR<\/h3>\n\n\n\n<div class=\"wp-block-columns alignfull is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<div id=\"wp-block-themeisle-blocks-advanced-columns-a2946a77\" class=\"wp-block-themeisle-blocks-advanced-columns alignwide has-2-columns has-desktop-equal-layout has-tablet-equal-layout has-mobile-collapsedRows-layout has-vertical-unset ticss-a2946a77 has-light-bg\"><div class=\"wp-block-themeisle-blocks-advanced-columns-overlay\"><\/div><div class=\"innerblocks-wrap\">\n<div id=\"wp-block-themeisle-blocks-advanced-column-bbddf55b\" class=\"wp-block-themeisle-blocks-advanced-column\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<h2 class=\"wp-block-heading\"><img decoding=\"async\" style=\"width: 491px;\" src=\"https:\/\/lh7-rt.googleusercontent.com\/docsz\/AD_4nXeUDEcm7gkz5EdPztvZxVdrtlLbou9HTr_y9zoTB2llFrq9LztDm-CLoP58wjcEkGrTfqyuMdWxKx37rrSsC2b4hJ1mn6_5d3eI-499O1a_wR0LDtgeDI_8RSdTK5WlSB6wFEjaG79_mEdakdVtYbAX0BA?key=zbOsfNziTzo7HzdIEpvRkA\"><\/h2>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1038\/s41467-023-40089-0\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-neve-text-color-color\">Source: <em>Nat Commun<\/em> 14, 4351 (2023)<\/mark><\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div id=\"wp-block-themeisle-blocks-advanced-column-92b2db05\" class=\"wp-block-themeisle-blocks-advanced-column\">\n<ul class=\"wp-block-list\">\n<li>The first and only polymer platform with an inherent imaging signal from the polymer backbone, achieved through a unique molecular design, enables the detection of biocompatible, non-radioactive <sup>31<\/sup>P.<\/li>\n\n\n\n<li>No need for toxic or persistent substances like heavy-metal chelates, ensuring safety and sustainability.<\/li>\n\n\n\n<li>Background-free <sup>31<\/sup>P detection and quantification using &#8220;hotspot&#8221; MRI: Clear signal detection in a distinct &#8220;color,&#8221; completely independent of anatomical background, allows for precise visualization, localization, and tracking of in vivo changes of the material, such as degradation<\/li>\n\n\n\n<li>Unique, versatile use as a highly informative hotspot MRI agent or as a building block for novel nanomedicines and biomaterials with inherent imaging capabilities<\/li>\n<\/ul>\n<\/div>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<h3 class=\"wp-block-heading alignwide has-text-align-left\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-neve-text-color-color\">Early cancer detection and advanced therapeutics<\/mark><\/strong><\/h3>\n\n\n\n<div style=\"height:8px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<div class=\"wp-block-cover alignfull\" style=\"min-height:356px;aspect-ratio:unset;\"><span aria-hidden=\"true\" class=\"wp-block-cover__background has-background-dim\"><\/span><img decoding=\"async\" width=\"1024\" height=\"576\" class=\"wp-block-cover__image-background wp-image-979\" alt=\"\" src=\"https:\/\/phos4nova.eu\/wp-content\/uploads\/2025\/04\/sea-6159674_1920-1024x576.jpg\" data-object-fit=\"cover\" srcset=\"https:\/\/phos4nova.eu\/wp-content\/uploads\/2025\/04\/sea-6159674_1920-1024x576.jpg 1024w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2025\/04\/sea-6159674_1920-300x169.jpg 300w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2025\/04\/sea-6159674_1920-768x432.jpg 768w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2025\/04\/sea-6159674_1920-1536x864.jpg 1536w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2025\/04\/sea-6159674_1920.jpg 1920w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><div class=\"wp-block-cover__inner-container is-layout-flow wp-block-cover-is-layout-flow\">\n<h4 class=\"wp-block-heading alignwide has-text-align-left\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-nv-light-bg-color\">Phos4nova leverages Phos4MR technology to develop efficient imaging agents that enable the early detection of cancer.<\/mark><\/h4>\n\n\n\n<h4 class=\"wp-block-heading alignwide has-text-align-left\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-nv-light-bg-color\">We envision revolutionizing the diagnosis of particularly challenging solid tumors, such as liver and colorectal cancer.<\/mark> <mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-nv-light-bg-color\">Through early diagnosis, we anticipate enabling better and more efficient cancer treatment, allowing more patients to become cancer-free.<\/mark><\/h4>\n\n\n\n<h4 class=\"wp-block-heading alignwide has-text-align-left\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-nv-light-bg-color\">Furthermore, we aim to empower scientists to develop novel, powerful therapies. Therefore, we are seeking partnerships to utilize Phos4MR technology in the development of advanced nanomedicines and biomaterials for personalized treatments.<\/mark><\/h4>\n<\/div><\/div>\n\n\n\n<div style=\"height:46px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading alignfull has-text-align-center has-nv-light-bg-color has-midnight-gradient-background has-text-color has-background has-link-color wp-elements-cc33526378b002d2d4290f1f922648b7\" style=\"padding-top:var(--wp--preset--spacing--50);padding-bottom:var(--wp--preset--spacing--50)\">PPEylate<sup>\u00ae <\/sup>The Biodegradable PEG Alternative for Enhanced Drug Delivery<\/h2>\n\n\n\n<div style=\"height:26px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading alignwide has-text-align-center\">TECHNOLOGY: PPEylate<sup>\u00ae<\/sup><br><\/h3>\n\n\n\n<div class=\"wp-block-group alignwide has-nv-light-bg-background-color has-background is-content-justification-center is-nowrap is-layout-flex wp-container-core-group-is-layout-314ac680 wp-block-group-is-layout-flex\" style=\"border-style:none;border-width:0px;padding-top:2vw;padding-right:6vw;padding-bottom:2vw;padding-left:6vw\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" width=\"1024\" height=\"545\" src=\"https:\/\/phos4nova.eu\/wp-content\/uploads\/2025\/04\/Capture-decran-2025-04-09-a-16.53.18-1-1024x545.png\" alt=\"\" class=\"wp-image-977\" srcset=\"https:\/\/phos4nova.eu\/wp-content\/uploads\/2025\/04\/Capture-decran-2025-04-09-a-16.53.18-1-1024x545.png 1024w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2025\/04\/Capture-decran-2025-04-09-a-16.53.18-1-300x160.png 300w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2025\/04\/Capture-decran-2025-04-09-a-16.53.18-1-768x409.png 768w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2025\/04\/Capture-decran-2025-04-09-a-16.53.18-1.png 1056w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-vertically-aligned-center is-layout-flow wp-block-column-is-layout-flow\" style=\"border-style:none;border-width:0px;padding-top:0;padding-right:0;padding-bottom:0;padding-left:0\">\n<ul class=\"wp-block-list\">\n<li>Stabilizes nanoparticles in blood, preventing aggregation and ensuring efficient targeting<\/li>\n\n\n\n<li>Provides a superior stealth effect, minimizing immune cell uptake and prolonging circulation<\/li>\n\n\n\n<li>Avoids anti-PEG antibodies, improving safety and efficacy<\/li>\n\n\n\n<li>Enables the formulation of innovative MRI-traceable theranostic materials when combined with Phos4MR\u2122 technology<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:45px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading alignwide\">PPEylate is a result of long-standing fundamental research by Phso4\u2019nova\u2019s co-founder Frederik Wurm and other researchers. <br><br>You can find more information here :<\/h5>\n\n\n\n<div class=\"wp-block-columns alignwide is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<p>Sch\u00f6ttler, S.; Becker, G.; Winzen, S.; Steinbach, T.; Mohr, K.; Landfester, K.; Mail\u00e4nder, V.; Wurm, F. R., Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers. <em>Nat. Nanotechnol. <\/em><strong>2016,<\/strong> <em>11<\/em> (4), 372-377.<br><a href=\"https:\/\/www.nature.com\/articles\/nnano.2015.330\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-neve-link-hover-color-color\">https:\/\/www.nature.com\/articles\/nnano.2015.330<\/mark><\/a><br><br>Simon, J.; Wolf, T.; Klein, K.; Landfester, K.; Wurm, F. R.; Mail\u00e4nder, V., Hydrophilicity Regulates the Stealth Properties of Polyphosphoester-Coated Nanocarriers. <em>Angew Chem Int Ed Engl <\/em><strong>2018,<\/strong> <em>57<\/em> (19), 5548-5553. <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201800272\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-nv-dark-bg-color\">https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/anie.201800272<\/mark><\/a><br><br>Pelosi, C.; Tin\u00e8, M. R.; Wurm, F. R., Main-chain water-soluble polyphosphoesters: Multi-functional polymers as degradable PEG-alternatives for biomedical applications. <em>Eur. Polym. J. <\/em><strong>2020,<\/strong> <em>141<\/em>, 110079.<br><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014305720317936\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-neve-link-hover-color-color\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0014305720317936<\/mark><\/a><\/p>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading alignfull has-text-align-center has-nv-site-bg-color has-midnight-gradient-background has-text-color has-background has-link-color wp-elements-788db5b74956be24ec885f85a9c43467\">Applications of PPEylate<sup>\u00ae<\/sup><\/h2>\n\n\n\n<div style=\"height:54px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<figure class=\"wp-block-gallery alignfull has-nested-images columns-default is-cropped wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" data-id=\"842\" src=\"https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-3-1-1024x1024.png\" alt=\"\" class=\"wp-image-842\" srcset=\"https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-3-1-1024x1024.png 1024w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-3-1-300x300.png 300w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-3-1-150x150.png 150w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-3-1-768x768.png 768w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-3-1.png 1536w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-neve-text-color-color\">Formulation of hydrogels and biomaterials<br><\/mark><\/strong><\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" data-id=\"844\" src=\"https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-2-1-1024x1024.png\" alt=\"\" class=\"wp-image-844\" srcset=\"https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-2-1-1024x1024.png 1024w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-2-1-300x300.png 300w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-2-1-150x150.png 150w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-2-1-768x768.png 768w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-2-1.png 1536w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-neve-text-color-color\">Stabilization of peptide and protein therapeutics<br><\/mark><\/strong><\/figcaption><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"1024\" data-id=\"843\" src=\"https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-3-2-1024x1024.png\" alt=\"\" class=\"wp-image-843\" srcset=\"https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-3-2-1024x1024.png 1024w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-3-2-300x300.png 300w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-3-2-150x150.png 150w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-3-2-768x768.png 768w, https:\/\/phos4nova.eu\/wp-content\/uploads\/2024\/08\/unnamed-3-2.png 1536w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/><figcaption class=\"wp-element-caption\"><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-neve-text-color-color\">Formulation of hydrogels and biomaterials<br><\/mark><\/strong><\/figcaption><\/figure>\n<\/figure>\n\n\n\n<div style=\"height:21px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Phos4MR Revolutionizing medical imaging and materials through the world\u2019s first polymers with inherent imaging signal TECHNOLOGY: Phos4MR Early cancer detection and advanced therapeutics PPEylate\u00ae The Biodegradable PEG Alternative for Enhanced Drug Delivery TECHNOLOGY: PPEylate\u00ae PPEylate is a result of long-standing fundamental research by Phso4\u2019nova\u2019s co-founder Frederik Wurm and other researchers. You can find more information&hellip;&nbsp;<a href=\"https:\/\/phos4nova.eu\/?page_id=493\" rel=\"bookmark\">Read More &raquo;<span class=\"screen-reader-text\">Our Technology<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_uag_custom_page_level_css":"","neve_meta_sidebar":"","neve_meta_container":"","neve_meta_enable_content_width":"off","neve_meta_content_width":100,"neve_meta_title_alignment":"","neve_meta_author_avatar":"","neve_post_elements_order":"","neve_meta_disable_header":"","neve_meta_disable_footer":"","neve_meta_disable_title":"","neve_meta_reading_time":"","_themeisle_gutenberg_block_has_review":false,"footnotes":"[]"},"class_list":["post-493","page","type-page","status-publish","hentry"],"uagb_featured_image_src":{"full":false,"thumbnail":false,"medium":false,"medium_large":false,"large":false,"1536x1536":false,"2048x2048":false,"neve-blog":false},"uagb_author_info":{"display_name":"phos4nova.eu","author_link":"https:\/\/phos4nova.eu\/?author=1"},"uagb_comment_info":0,"uagb_excerpt":"Phos4MR Revolutionizing medical imaging and materials through the world\u2019s first polymers with inherent imaging signal TECHNOLOGY: Phos4MR Early cancer detection and advanced therapeutics PPEylate\u00ae The Biodegradable PEG Alternative for Enhanced Drug Delivery TECHNOLOGY: PPEylate\u00ae PPEylate is a result of long-standing fundamental research by Phso4\u2019nova\u2019s co-founder Frederik Wurm and other researchers. You can find more information&hellip;&nbsp;Read&hellip;","_links":{"self":[{"href":"https:\/\/phos4nova.eu\/index.php?rest_route=\/wp\/v2\/pages\/493","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/phos4nova.eu\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/phos4nova.eu\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/phos4nova.eu\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/phos4nova.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=493"}],"version-history":[{"count":68,"href":"https:\/\/phos4nova.eu\/index.php?rest_route=\/wp\/v2\/pages\/493\/revisions"}],"predecessor-version":[{"id":988,"href":"https:\/\/phos4nova.eu\/index.php?rest_route=\/wp\/v2\/pages\/493\/revisions\/988"}],"wp:attachment":[{"href":"https:\/\/phos4nova.eu\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=493"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}