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Our Technology

Our technology helps clinicians achieve early diagnoses and effective therapies, while enabling scientists to develop new therapeutic materials.

TECHNOLOGY: Phos4MR

  • The first and only polymer platform with an inherent imaging signal from the polymer backbone, achieved through a unique molecular design, enables the detection of biocompatible, non-radioactive 31P.
  • No need for toxic or persistent substances like heavy-metal chelates, ensuring safety and sustainability.
  • Background-free 31P detection and quantification using « hotspot » MRI: Clear signal detection in a distinct « color, » completely independent of anatomical background, allows for precise visualization, localization, and tracking of in vivo changes of the material, such as degradation
  • Unique, versatile use as a highly informative hotspot MRI agent or as a building block for novel nanomedicines and biomaterials with inherent imaging capabilities

TECHNOLOGY: PPEylate®

  • Stabilizes nanoparticles in blood, preventing aggregation and ensuring efficient targeting
  • Provides a superior stealth effect, minimizing immune cell uptake and prolonging circulation
  • Avoids anti-PEG antibodies, improving safety and efficacy
  • Enables the formulation of innovative MRI-traceable theranostic materials when combined with Phos4MR™ technology
PPEylate is a result of long-standing fundamental research by Phso4’nova’s co-founder Frederik Wurm and other researchers.

You can find more information here :

Schöttler, S.; Becker, G.; Winzen, S.; Steinbach, T.; Mohr, K.; Landfester, K.; Mailänder, V.; Wurm, F. R., Protein adsorption is required for stealth effect of poly(ethylene glycol)- and poly(phosphoester)-coated nanocarriers. Nat. Nanotechnol. 2016, 11 (4), 372-377.
https://www.nature.com/articles/nnano.2015.330

Simon, J.; Wolf, T.; Klein, K.; Landfester, K.; Wurm, F. R.; Mailänder, V., Hydrophilicity Regulates the Stealth Properties of Polyphosphoester-Coated Nanocarriers. Angew Chem Int Ed Engl 2018, 57 (19), 5548-5553. https://onlinelibrary.wiley.com/doi/10.1002/anie.201800272

Pelosi, C.; Tinè, M. R.; Wurm, F. R., Main-chain water-soluble polyphosphoesters: Multi-functional polymers as degradable PEG-alternatives for biomedical applications. Eur. Polym. J. 2020, 141, 110079.
https://www.sciencedirect.com/science/article/pii/S0014305720317936